Teams at Altos Labs

Leads lab-in-the-loop biology programs that connect experimental design with machine learning model development. Oversees closed-loop experiments, model-output verification, perturbation studies, data generation, assay and model-system development, automation, metadata standards, CRO and vendor relationships, budgets, and cross-functional collaboration. Builds and mentors technical teams while aligning experimental and computational groups across a matrixed biotech organization.

Conduct membrane and lipid biochemistry research supporting brain aging and neurodegeneration programs. Design protein expression constructs, perform mammalian recombinant expression and purification, reconstitute membrane proteins, prepare cryo-EM samples, and characterize protein purity, stability, binding kinetics, activity, and oligomerization. Develop assays and SOPs, document experiments rigorously, troubleshoot independently, manage multiple priorities, and coordinate with CROs for material generation and analysis.

Executes rodent in vivo studies across multiple drug discovery programs, including dosing, blood collection, necropsy, tissue harvesting, sample processing, animal monitoring, and study documentation. Coordinates timelines and sample needs with scientists, operational leads, and vivarium staff. Ensures IACUC compliance, animal welfare, data integrity, and protocol adherence while troubleshooting routine issues. Provides technical training and flexible weekend or time-sensitive study coverage.